CAKMAK

    LAB

yusuf.cakmak@otago.ac.nz

Tel: +64-3-479-4030

Department of Anatomy
Otago School of Medical Sciences PO Box 56
Dunedin 9054
New Zealand

LINKS
ABOUT
TEACHING
  
         
Yusuf Ozgur Cakmak, MD, PhD

 
 
Postgraduate Diploma in Surgical Anatomy
Postgraduate Diploma in Ophthalmology
Basic Science Course for Royal Australasia College of Surgeons Exams(FRACS)
Med2 Respiratory Anatomy
Dentistry Head and Neck Anatomy
ANAT335 Neuromodulation
NEUR452 Peripheral Nerve Stimulation
 

 
 
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 RESEARCH  FOCUS:

 
WEARABLE SYSTEMS 
NON
-INVASIVE 
NEUROMODULATION

MOBILE HEALTH
APPLICATIONS

EDUCATION TECHNOLOGY
SELF-DIRECTED & DISTANCE LEARNING

 

 
NON-INVASIVE 
NEUROMODULATION

WEARABLE
SYSTEMS

01 / NON-INVASIVE                         NEUROMODULATION
        OF THE INTERNAL                   ORGAN'S BLOOD
        FLOW

 We had mapped and have been mapping the dermatomes, perforating artery zones and related internal organ arteries with different
skin stimulation frequency combinations to modulate the internal organ blood flow. We have a granted patent for the technique.

02 / NON-INVASIVE
        NEUROMODULATION         FOR PARKINSON'S             DISEASE

  To alleviate the PD symptoms

we are using a methodology in which we stimulate the autonomic and 3 peripheral nerves 
simultaneously with one compact device.
  We recently finished a Clinical trial by using our compact wearable device and one related patent is granted and two more patent applications are pending.

 

03 /  NON-INVASIVE
              MODULATION OF                CRANIAL NERVES

  A majority of the Neurological diseases and symptoms holds a potential to be altered with pathophysiology specific cranial
nerve stimulation.
  We recently published a research
of unique stimulation of vestibular nerve. 

  In another clinical trial we demonstrated the improvement of human olfactory function with
non-invasive auricular electrostimulation for the first time
in the literature.

01 / NON-INVASIVE NEUROMODULATION OF            THE INTERNAL ORGAN'S BLOOD FLOW

Patent granted in US/EU/Japan

02 / NON-INVASIVE                     NEUROMODULATION          FOR PARKINSON'S
        DISEASE

Auricular Electrostimulation for Parkinson's Disease
Clinical Trial paper 1 

Auricular Neuroprosthetics paper 

 Our another Parkinson paper was
         in the focus of media.

and PPN.

Illustratio from Complete Anatomy

Moderate to High Clinical Significance is obtained with intrinsic Auricular muscle zone stimulation in 24 patients in a double-blinded, placebo &sham controlled clinical trial (link  to the paper is on the left).                                                                                                                                                                                                                                                                                                                                                                                                       

A novel non-invasive wearable electrostimulator for Parkinson's Disease

1

Patent granted in US/EU/Japan

 US REGISTERED CLINICAL TRIAL 2                                   

Screen Shot 2019-06-10 at 4.49.54 PM.png

  Based on our innovation and wearable device US-based company "Stoparkinson Healthcare Systems LLC"  established by Inventram & Mitsui companies.

    We presented our second clinical trial results in World Parkinson's Congress, 2019 Kyoto. In this trial, we demonstrated the effect of the stimulator is faster than the PD medications and can be used in combination with

medications for better results in a motion-capture study. In addition, we demonstrated that the 20 minutes of the stimulation has prolonged effects after the stim turned off. Click on the video below for the animated results.

03 / NON-INVASIVE
       MODULATION OF           CRANIAL NERVES

NON-INVASIVE
 VESTIBULAR
    SYSTEM STIMULATION
         &

 STRUCTURAL
 PLASTICITY

ANZCTR

Australian and New Zealand Registered Clinical Trial for
Olfactory Nerve Modulation
             MODOLF

IMPROVING AND SUPPRESSING THE   OLFACTORY FUNCTIONS  WITH NON-INVASIVE
NERVE STIMULATION
         

  With a Medtech Core NZ granted project,
we are deve on a wearable system to modulate gastric functions with cranial nerve stimulation in collaboration  with Auckland Bioengineering Institute.

01 Non-invasive & Non-contact systems for
    Cardiovascular Disease Diagnosis & Monitoring 

 

 
MOBILE HEALTH
APPLICATIONS

Carotid artery waveforms -
Chapter/p83

Screen Shot 2017-11-03 at 2.37.24 pm.png

We developed a non-contact and non-invasive system for mobile devices with an ordinary camera to diagnose and monitor CVS diseases in collaboration with Auckland Bioengineering Institute with a Medtech Core granted project.

Jugular vein waveforms -Article

   We published a research
in 
Atherosclerosis journal
in which we demonstrated
a correlation in between the finger length ratio and atherosclerosis level in coronary arteries.

  The outcomes and method of this study used as a proxy

to build a mobile application

Learn Risk : is an ios application
based on our research paper in
Atherosclerosis in which we demonstrated the relationship of the 2D:4D digit ratio and the level of atherosclerosis in the coronary arteries.

In collaboration with Tecnoface

Listed in itunes

02 Mobile phone app for CVS risk monitoring with hand morphology
 

03 Mobile phone app for Acoustic Startle Reflex Monitoring (MARS): A remote monitoring system for post-traumatic stress disorder

US patent pending

04 Non-contact and automated systems to
   determine Parkinson's Disease symptoms
   (Tremor, Bradykinesia, Rigidity & Gait)

In collaboration with Johns Hopkins University

Screen Shot 2019-05-22 at 11.14.49 AM.pn

Click on the image above to read a part of our research as a manuscript in Biosignals 2018
Our other approaches are pending for IP

05 Non-contact mobile phone application
   to monitor Parkinson's Disease patients'
   motor capabilities  
  

Clinical trial in progress

 
EDUCATION TECHNOLOGY
Self-Directed & Distance Learning Systems



  A software development for 3D textured digitalisation and annotation of human cadaveric specimens for distance learning, revision, lab manual and 
multiviewer Hololens mixed reality implementation for holographic cadaveric teaching/learning.

INTERNATIONALISATION OF THE CURRICULUM GRANT PROJECT
 

HOLOGRAMIC Interactive Visual System- Chris Wang &Yusuf Cakmak 
Interactive ANATOMY and PATHOLOGIES

 

IMPACT

 

LAB      MEMBERS

Prashanna Khwaounjoo, PhD

Postdoctoral Researcher
Data Scientist

Chris Gowen, BSc

MSc Candidate 
 

Burak Ozsoy, PhD

Postdoctoral Researcher
Parkinson Device Start-up Company Operations Manager

Alexander Yang

PGDipSci 

Ashim Maharjan, MSc

PhD Candidate 
 

Gurleen Singh

PGDipSci 

Susannah Lumsden, MSc

PhD Candidate

Catherine Spicer

PGDipSci 

Chris Wang

BMedSc(Hons)

Uliana Sekene

PGDipSci 

 

   PhD OPPORTUNITIES ARE AVAILABLE
       FOR MSc GRADUATES WITH A+
          
with a Scholarship possibility
           for suitably qualified applicants

     
   

Muscular Hand Avatar was in the Science Expo 2016

Southwest Research Institute (Texas)
produced the first prototype for our innovation- the blood flow modulation device
 (Granted in Japan and US ) 

  We have been invited to Voice of America Washington to talk about our innovation.

 INVENTRAM & MITSUI  

       We had positive results in clinical
trials and 
Inventram & Mitsui  proceeded
 with launching STOParkinson company and new product design for our non-invasive 
wearable device for Parkinson's Disease.
    We will be running another US-based multicentric clinical trial in 2019. 
  


 

HOT NEWS

We started a novel biomedical device research in Charles Perkins Centre,
Hybrid Theatre at the University of Sydney
 with Siemens iflow technology.

Kudos to our great team and Siemens support.

 
Click to watch Alex and Gurleen in TEXPO


Alex and Gurleen presented 2 of our lab 
projects in Texpo

 

TEXPO 
 2019