SELF-DIRECTED & DISTANCE LEARNING
01 / NON-INVASIVE NEUROMODULATION
OF THE INTERNAL ORGAN'S BLOOD
We had mapped and have been mapping the dermatomes, perforating artery zones and related internal organ arteries with different
skin stimulation frequency combinations to modulate the internal organ blood flow. We have a granted patent for the technique.
02 / NON-INVASIVE
NEUROMODULATION FOR PARKINSON'S DISEASE
To alleviate the PD symptoms
we are using a methodology in which we stimulate the autonomic and 3 peripheral nerves
simultaneously with one compact device.
We recently finished a Clinical trial by using our compact wearable device and one related patent is granted and two more patent applications are pending.
03 / NON-INVASIVE
MODULATION OF CRANIAL NERVES
A majority of the Neurological diseases and symptoms holds a potential to be altered with pathophysiology specific cranial
We recently published a research
of unique stimulation of vestibular nerve.
In another clinical trial we demonstrated the improvement of human olfactory function with
non-invasive auricular electrostimulation for the first time
in the literature.
01 / NON-INVASIVE NEUROMODULATION OF THE INTERNAL ORGAN'S BLOOD FLOW
Patent granted in US/EU/Japan
02 / NON-INVASIVE NEUROMODULATION FOR PARKINSON'S
Auricular Electrostimulation for Parkinson's Disease
Clinical Trial paper 1
Auricular Neuroprosthetics paper
Our another Parkinson paper was
in the focus of media.
A novel non-invasive wearable electrostimulator for Parkinson's Disease
Patent granted in US/EU/Japan
Illustratio from Complete Anatomy
Moderate to High Clinical Significance is obtained with intrinsic Auricular muscle zone stimulation in 24 patients in a double-blinded, placebo &sham controlled clinical trial (link to the paper is on the left,
Clinical Trial paper 1).
US REGISTERED CLINICAL TRIAL 2
We presented our second clinical trial results in World Parkinson's Congress, 2019 Kyoto. In this trial, we demonstrated the effect of the stimulator is faster than the PD medications and can be used in combination with
medications for better results in a motion-capture study. In addition, we demonstrated that the 20 minutes of the stimulation has prolonged effects after the stim turned off. Click on the video below for the animated results.
Based on our innovation and wearable device US-based company "Stoparkinson Healthcare Systems LLC" established by Inventram & Mitsui companies.
We performed our first meeting with FDA in 2020
03 / NON-INVASIVE
MODULATION OF CRANIAL NERVES
Australian and New Zealand Registered Clinical Trial for
Olfactory Nerve Modulation
IMPROVING AND SUPPRESSING THE OLFACTORY FUNCTIONS WITH NON-INVASIVE
In both Alzheimer's and Parkinson Disease, olfactory bulb and olfactory system demonstrate dysfunction in addition to the disease-associated pathologies at the very early stages of these diseases. In this context, the stimulation of the olfactory system may have the potential of slowing down the disease progression or alleviating the olfactory dysfunction and associated symptoms.
Suppression of the appetite-related
olfactory activity may have potential
beneficial effects on eating disorders and
With a Medtech Core NZ granted project,
we are developing a wearable system to modulate gastric functions with cranial nerve stimulation in collaboration with Auckland Bioengineering Institute.
Our gastric neuromodulation paper
01 Non-invasive & Non-contact systems for
Cardiovascular Disease Diagnosis & Monitoring
We published a research
in Atherosclerosis journal
in which we demonstrated
a correlation in between the finger length ratio and atherosclerosis level in coronary arteries.
The outcomes and method of this study used as a proxy
to build a mobile application
Learn Risk : is an ios application
based on our research paper in
Atherosclerosis in which we demonstrated the relationship of the 2D:4D digit ratio and the level of atherosclerosis in the coronary arteries.
In collaboration with Tecnoface
Listed in itunes
02 Mobile phone app for CVS risk monitoring with hand morphology
03 Mobile phone app for Acoustic Startle Reflex Monitoring (MARS): A remote monitoring system for post-traumatic stress disorder
US patent pending
04 Non-contact and automated systems to
determine Parkinson's Disease symptoms
(Tremor, Bradykinesia, Rigidity & Gait)
In collaboration with Johns Hopkins University
Click on the image above to read a part of our research as a manuscript in Biosignals 2018
Our other approaches are pending for IP
05 Non-contact mobile phone application
to monitor Parkinson's Disease patients'
Clinical trial in progress
Self-Directed & Distance Learning Systems
IEEE Transactions on Learning Technologies
Our article about Hand Avatar is published in the
A software development for 3D textured digitalisation and annotation of human cadaveric specimens for distance learning, revision, lab manual and
multiviewer Hololens mixed reality implementation for holographic cadaveric teaching/learning.
INTERNATIONALISATION OF THE CURRICULUM GRANT PROJECT
HOLOGRAPHIC Interactive Visual System-
Interactive ANATOMY and PATHOLOGIES
IN THE NEWS
NZHerald, NZ 2017 May
Otago Daily Times , NZ 2017 May
NZdoctor.co.nz, NZ 2017 May
Voice of America , US 2016 May
Fox tv TR 2016
Newsweek TR 3 issues,cover in 2012
Science Focus TR 2011 March
Medtech Core NZ
Otago Innovation NZ
Inventram TR/ Mitsui JPN
SouthWest Research Institute US
Columbia University US
Maastricht University NL
Auckland University NZ
Auckland Bioengineering Institute NZ
Sydney University, AU
New York University, US
Koc University TR
Parkinson Study Group, US
NeSI-HPC supercomputer, NZ
Johns Hopkins University, US
Fisher & Paykel Healthcare, NZ
A system for decreasing the blood flow of a targeted organ's artery with an electrical stimulation
Granted in US, EU & Japan
An electrostimulation device for PD
WO 2014207512 A1
Granted in EU and US
A system for Monitoring Auditory Startle Response
Electrostimulation device for the external ear canal
Electrostimulation device effective in muscle localisation identification and therapeutic response enhancement
A system for decreasing the blood glucose level
A system for decreasing the blood pressure
A system for Monitoring Auditory Startle Response: Mobile monitoring of the Startle reflex
with intrinsic auricular muscles and camera-based systems
US15/642,287 209/000845 A1
Non-Invasive Stimulation Device for Synchronous stimulation of Sternocleidomastoid muscles and four
of the cutaneous Cervical nerve Branches with their autonomic connections
Prashanna Khwaounjoo, PhD
Burak Ozsoy, PhD
Parkinson Device Start-up Company Operations Manager
Ashim Maharjan, MSc
Susannah Lumsden, MSc
Alexander Yang, BSc
Chris Gowen, BSc
(from University of Groningen)
Internship student (MSc)
(from University of Leiden)
Dr.Cakmak performed a live demonstration & lecture
on Neuronavigation guided Transcranial magnetic stimulation
for the European Medical Student Association - EMSA
Muscular Hand Avatar was in the Science Expo 2016
Southwest Research Institute (Texas)
produced the first prototype for our innovation- the blood flow modulation device
(Granted in Japan and US )
We have been invited to Voice of America Washington to talk about our innovation.
INVENTRAM & MITSUI
We had positive results in clinical
trials and Inventram & Mitsui proceeded
with launching STOParkinson company and new product design for our non-invasive wearable device for Parkinson's Disease.
We will be running another US-based multicentric clinical trial in 2020-21.
We started a novel biomedical device research in Charles Perkins Centre,
Hybrid Theatre at the University of Sydney with Siemens iflow technology.
Kudos to our great team and Siemens support.
Alex and Gurleen presented 2 of our lab
projects in Texpo
We performed our first meeting with FDA (The Food and Drug Administration, a federal agency of the United States Department of Health and Human Services) for our wearable stimulator for Parkinson's Disease in 2020.