CAKMAK
LAB
UNIVERSITY OF OTAGO
Te Whare Wānanga o Otāgo
RESEARCH FOCUS:
WEARABLE SYSTEMS
NON-INVASIVE
NEUROMODULATION
MOBILE HEALTH
APPLICATIONS
EDUCATION TECHNOLOGY
SELF-DIRECTED & DISTANCE LEARNING
NON-INVASIVE
NEUROMODULATION
WEARABLE
SYSTEMS
01 / NON-INVASIVE NEUROMODULATION
OF THE INTERNAL ORGAN'S BLOOD
FLOW
We had mapped and have been mapping the dermatomes, perforating artery zones and related internal organ arteries with different
skin stimulation frequency combinations to modulate the internal organ blood flow. We have a granted patent for the technique.
02 / NON-INVASIVE
NEUROMODULATION FOR PARKINSON'S DISEASE
To alleviate the PD symptoms
we are using a methodology in which we stimulate the autonomic and 3 peripheral nerves
simultaneously with one compact device.
We recently finished a Clinical trial by using our compact wearable device and one related patent is granted and two more patent applications are pending.
03 / NON-INVASIVE
MODULATION OF CRANIAL NERVES
A majority of the Neurological diseases and symptoms holds a potential to be altered with pathophysiology specific cranial
nerve stimulation.
We recently published a research
of unique stimulation of vestibular nerve.
In another clinical trial we demonstrated the improvement of human olfactory function with
non-invasive auricular electrostimulation for the first time
in the literature.
01 / NON-INVASIVE NEUROMODULATION OF THE INTERNAL ORGAN'S BLOOD FLOW
Patent granted in US/EU/Japan
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02 / NON-INVASIVE NEUROMODULATION FOR PARKINSON'S
DISEASE
Auricular Electrostimulation for Parkinson's Disease
Clinical Trial paper 1
Auricular Neuroprosthetics paper
A novel non-invasive wearable electrostimulator for Parkinson's Disease
Patent granted in US/EU/Japan
1
and PPN.
Illustration from Complete Anatomy
Our another Parkinson paper was
in the focus of media.
Moderate to High Clinical Significance is obtained with intrinsic Auricular muscle zone stimulation in 24 patients in a double-blinded, placebo &sham controlled clinical trial
(link to the paper is on the left upper column,
Clinical Trial paper 1).
US REGISTERED CLINICAL TRIAL 2
We presented our second clinical trial results in World Parkinson's Congress, 2019 Kyoto. In this trial, we demonstrated the effect of the stimulator is faster than the PD medications and can be used in combination with
medications for better results in a motion-capture study. In addition, we demonstrated that the 20 minutes of the stimulation has prolonged effects after the stim turned off. Click on the video below for the animated results.
In 2020, we also published our results in Frontiers in Neurology. Please click on the Frontiers icon to access the full text of the paper.
US-based Spin-out Company
Based on our innovation and wearable device US-based company "Stoparkinson Healthcare Systems LLC" established by Inventram & Mitsui companies.
We performed our first meeting with FDA in 2020
Auricular Electrostimulation for Parkinson's Disease
Clinical Trial paper 2
03 / NON-INVASIVE
MODULATION OF CRANIAL NERVES
NON-INVASIVE
VESTIBULAR
SYSTEM STIMULATION
&
STRUCTURAL
PLASTICITY
In both Alzheimer's and Parkinson Disease, olfactory bulb and olfactory system demonstrate dysfunction in addition to the disease-associated pathologies at the very early stages of these diseases. In this context, the stimulation of the olfactory system may have the potential of slowing down the disease progression or alleviating the olfactory dysfunction and associated symptoms.
IMPROVING AND SUPPRESSING THE OLFACTORY FUNCTIONS WITH NON-INVASIVE
NERVE STIMULATION
ANZCTR
Australian and New Zealand Registered Clinical Trial
for Olfactory Nerve Modulation- MODOLF
Suppression of the appetite-related
olfactory activity may have potential
beneficial effects on eating disorders and
associated problems.
Wearable Stimulator for Olfactory Nerve
In collaboration with SOTERIX, NY
Neuromodulation with
Virtual Reality
Selective stimulation of Vestibular and Visual neural networks to modulate
vagal activity
With the Medtech Core NZ granted projects (2017 & 2020),
we are developing a wearable system to modulate gastric functions with cranial nerve stimulation in collaboration with Auckland Bioengineering Institute.
Our non-invasive gastric neuromodulation paper
In collaboration with
UC Rose Centre for Stroke Recovery and Research
01 Non-invasive & Non-contact systems for
Cardiovascular Disease Diagnosis & Monitoring
MOBILE HEALTH
APPLICATIONS
Carotid artery waveforms -
Chapter/p83
We developed a non-contact and non-invasive system for mobile devices with an ordinary camera to diagnose and monitor CVS diseases in collaboration with Auckland Bioengineering Institute with a Medtech Core granted project.
Jugular vein waveforms -Article
We demonstrated that Human-Interfaced AI can modulate human(users) internal organ functions
via digital displays. No wearables or stimulators are needed.
New horizons for telehealth based neuromodulation but also highlight certain ethical aspects of AI.
02 NeuroModulation via Human-interfaced AI
Click on the Sensors image/icon to access the full text of our article
03 Mobile phone app for Acoustic Startle Reflex Monitoring (MARS) : A remote monitoring system for post-traumatic stress disorder
Click on the Sensors journal logo
to access our article
US patent granted
Clinical trials in collaboration with Johns Hopkins University
04 Non-contact and automated systems to
determine Parkinson's Disease symptoms
(Tremor, Bradykinesia, Rigidity & Gait)
Click on the image above to read a part of our research as a manuscript in Biosignals 2018
Our other approaches are pending for IP
05 Non-contact mobile phone application
to monitor Parkinson's Disease patients'
motor capabilities
Clinical trial in progress
EDUCATION TECHNOLOGY
Self-Directed & Distance Learning Systems
IEEE Transactions on Learning Technologies
Our article about Hand Avatar is published in the
Hand Avatar is used in numerous activities including Olympic Science at Lab in A Box by Otago Museum.
It was also in the news at Otago Daily Times (Click on the ODT logo for the news.)
A software development for 3D textured digitalisation and annotation of human cadaveric specimens for distance learning, revision, lab manual and
multiviewer Hololens mixed reality implementation for holographic cadaveric teaching/learning.
INTERNATIONALISATION OF THE CURRICULUM GRANT PROJECT
HOLOGRAPHIC Interactive Visual System-
Interactive ANATOMY and PATHOLOGIES
IMPACT
IN THE NEWS
BBC Future, 2021
Daily Mail, 2021
NZHerald, 2017
Otago Daily Times , 2017, 2021(2)
NZdoctor.co.nz, NZ 2017
Voice of America , US 2016
Fox Tv TR 2016
Newsweek TR 3 issues, cover in 2012
Science Focus TR 2011
SPONSORS
Medtech Core NZ
Otago Innovation NZ
Inventram TR/ Mitsui JPN
COLLABORATORS
SouthWest Research Institute US
Columbia University US
Harvard-Singapore University
Maastricht University NL
Auckland University NZ
Auckland Bioengineering Institute NZ
Sydney University, AU
New York University, US
Koc University TR
Codeflugel, AUSTRIA
Soterix, NY,US
Parkinson Study Group, US
NeSI-HPC supercomputer, NZ
Johns Hopkins University, US
Fisher & Paykel Healthcare, NZ
PATENTS
A system for decreasing the blood flow of a targeted organ's artery with an electrical stimulation
WO2014183790 A1
Granted in US, EU & Japan
An electrostimulation device for PD
WO 2014207512 A1
Granted in EU and US
A system for Monitoring Auditory Startle Response
US16/695,103
Electrostimulation device for the external ear canal
PCT/TR2016/050176
Electrostimulation device effective in muscle localisation identification and therapeutic response enhancement
PCT/TR2016/050064
A system for decreasing the blood glucose level
PCT/TR2016/000016
A system for decreasing the blood pressure
PCT/TR2016/000017
A system for Monitoring Auditory Startle Response: Mobile monitoring of the Startle reflex
with intrinsic auricular muscles and camera-based systems
US15/642,287 209/000845 A1
Non-Invasive Stimulation Device for Synchronous stimulation of Sternocleidomastoid muscles and four
of the cutaneous Cervical nerve Branches with their autonomic connections
PCT/TR2019/051093
LAB MEMBERS
Prashanna Khwaounjoo, PhD
Postdoctoral Researcher
Data Scientist
Burak Ozsoy, PhD
Postdoctoral Researcher
Parkinson Device Start-up Company Operations Manager
Ashim Maharjan, MSc
PhD Candidate
Susannah Lumsden, MSc
PhD Candidate
Alexander Yang, BSc
PhD Canditate
Susanne Feringa
Internship student
(from University of Groningen)
Chris Gowen, BSc
MSc Candidate
Mendy Zaal
Internship student (MSc)
(from University of Leiden)
Johanna Mathieson
BMedSci
Nikyta Chesney
PGDipSci
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Working Hard
ALUMNI 2018-2020
Chris Wang
BMedSc(Hons)
Uliana Sekene
PGDipSci
Gurleen Singh
PGDipSci
Catherine Spicer
PGDipSci
Ashim Maharjan
MSc
Chris Gowen
PGDipSci
Alexander Yang
PGdipSci
Dr.Cakmak performed a live demonstration & lecture
on Neuronavigation guided Transcranial magnetic stimulation
for the European Medical Student Association - EMSA
HOT NEWS
We started novel biomedical device research in Charles Perkins Centre, Hybrid Theatre at the University of Sydney with Siemens iflow technology. Kudos to our great team and Siemens support.
Alex and Gurleen presented 2 of our lab
projects in Texpo
TEXPO
2019
We performed our first meeting with FDA (The Food and Drug Administration,
a federal agency of the United States Department of Health and Human Services) for our wearable stimulator for Parkinson's Disease in 2020.
MEETING
PhD/MSc/BSci OPPORTUNITIES ARE AVAILABLE FOR GRADUATES WITH A+
(with a Scholarship possibility for suitably qualified PhD applicants)
AWARD
Nikyta Chesney
INVENTRAM & MITSUI
We had positive results in clinical
trials and Inventram & Mitsui proceeded
with launching STOParkinson company and new product design for our non-invasive wearable device for Parkinson's Disease.
We will be running another US-based multicentric clinical trial in 2020-21.
Southwest Research Institute (Texas)
produced the first prototype for our innovation-
the blood flow modulation device
(IP Granted in Japan and US )
We have been invited to Voice of America
Washington to talk about our innovation.
Postgraduate Diploma in Surgical Anatomy 2015- 2022
