RESEARCH  FOCUS:

 
WEARABLE SYSTEMS 
NON
-INVASIVE 
NEUROMODULATION

MOBILE HEALTH
APPLICATIONS

EDUCATION TECHNOLOGY
SELF-DIRECTED & DISTANCE LEARNING

 

 
NON-INVASIVE 
NEUROMODULATION

WEARABLE
SYSTEMS

01 / NON-INVASIVE                         NEUROMODULATION
        OF THE INTERNAL                   ORGAN'S BLOOD
        FLOW

 We had mapped and have been mapping the dermatomes, perforating artery zones and related internal organ arteries with different
skin stimulation frequency combinations to modulate the internal organ blood flow. We have a granted patent for the technique.

02 / NON-INVASIVE
        NEUROMODULATION         FOR PARKINSON'S             DISEASE

  To alleviate the PD symptoms

we are using a methodology in which we stimulate the autonomic and 3 peripheral nerves 
simultaneously with one compact device.
  We recently finished a Clinical trial by using our compact wearable device and one related patent is granted and two more patent applications are pending.

 

03 /  NON-INVASIVE
              MODULATION OF                CRANIAL NERVES

  A majority of the Neurological diseases and symptoms holds a potential to be altered with pathophysiology specific cranial
nerve stimulation.
  We recently published a research
of unique stimulation of vestibular nerve. 

  In another clinical trial we demonstrated the improvement of human olfactory function with
non-invasive auricular electrostimulation for the first time
in the literature.

01 / NON-INVASIVE NEUROMODULATION OF            THE INTERNAL ORGAN'S BLOOD FLOW

Patent granted in US/EU/Japan

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02 / NON-INVASIVE                     NEUROMODULATION          FOR PARKINSON'S
        DISEASE

Auricular Electrostimulation for Parkinson's Disease
Clinical Trial paper 1 

Auricular Neuroprosthetics paper 

 Our another Parkinson paper was
         in the focus of media.

and PPN.

A novel non-invasive wearable electrostimulator for Parkinson's Disease

1

Patent granted in US/EU/Japan

Illustration from Complete Anatomy

Moderate to High Clinical Significance is obtained with intrinsic Auricular muscle zone stimulation in 24 patients in a double-blinded, placebo &sham controlled clinical trial (link to the paper is on the left,
Clinical Trial paper 1).                                                                                                                                                                                                                                                                                                                                                                                                       

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 US REGISTERED CLINICAL TRIAL 2                                   

    We presented our second clinical trial results in World Parkinson's Congress, 2019 Kyoto. In this trial, we demonstrated the effect of the stimulator is faster than the PD medications and can be used in combination with

medications for better results in a motion-capture study. In addition, we demonstrated that the 20 minutes of the stimulation has prolonged effects after the stim turned off. Click on the video below for the animated results.
In 2020, we also published our results in Frontiers in Neurology. Please click on the Frontiers icon to access the full text of the paper.

US-based Spin-out Company

  Based on our innovation and wearable device US-based company "Stoparkinson Healthcare Systems LLC"  established by Inventram & Mitsui companies.


We performed our first meeting with FDA in 2020

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Auricular Electrostimulation for Parkinson's Disease
Clinical Trial paper 2

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03 / NON-INVASIVE
       MODULATION OF           CRANIAL NERVES
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NON-INVASIVE
 VESTIBULAR
    SYSTEM STIMULATION
         &

 STRUCTURAL
 PLASTICITY

In both Alzheimer's and Parkinson Disease, olfactory bulb and olfactory system demonstrate dysfunction in addition to the disease-associated pathologies at the very early stages of these diseases. In this context, the stimulation of the olfactory system may have the potential of slowing down the disease progression or alleviating the olfactory dysfunction and associated symptoms. 

ANZCTR

IMPROVING AND SUPPRESSING THE OLFACTORY FUNCTIONS  WITH NON-INVASIVE
NERVE STIMULATION
         

Australian and New Zealand Registered Clinical Trial
       for Olfactory Nerve Modulation- MODOLF

Suppression of the appetite-related
olfactory activity may have potential 
beneficial effects on eating disorders and
associated problems.

Wearable Stimulator for Olfactory Nerve

In collaboration with SOTERIX, NY

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Neuromodulation with 
Virtual Reality

Selective stimulation of Vestibular and Visual neural networks to modulate
vagal activity

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  With the Medtech Core NZ granted projects (2017 & 2020),
we are developing a wearable system to modulate gastric functions with cranial nerve stimulation in collaboration with Auckland Bioengineering Institute.

Our gastric neuromodulation paper 

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                          In collaboration with
UC Rose Centre for Stroke Recovery and Research

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01 Non-invasive & Non-contact systems for
    Cardiovascular Disease Diagnosis & Monitoring 

 

 
MOBILE HEALTH
APPLICATIONS

Carotid artery waveforms -
Chapter/p83

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We developed a non-contact and non-invasive system for mobile devices with an ordinary camera to diagnose and monitor CVS diseases in collaboration with Auckland Bioengineering Institute with a Medtech Core granted project.

Jugular vein waveforms -Article

    We demonstrated that Human-Interfaced AI can modulate human(users) internal organ functions
   via digital displays
. No wearables or stimulators are needed.

   New horizons for telehealth based neuromodulation but also highlight certain ethical aspects of AI.

02 NeuroModulation via Human-interfaced AI 
 

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Click on the image/icon to access the full text of our article

03 Mobile phone app for Acoustic Startle Reflex Monitoring (MARS): A remote monitoring system for post-traumatic stress disorder

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Click on the Sensors journal logo
to access our article

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US patent granted

Clinical trials in collaboration with Johns Hopkins University

04 Non-contact and automated systems to
   determine Parkinson's Disease symptoms
   (Tremor, Bradykinesia, Rigidity & Gait)

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Click on the image above to read a part of our research as a manuscript in Biosignals 2018
Our other approaches are pending for IP

05 Non-contact mobile phone application
   to monitor Parkinson's Disease patients'
   motor capabilities  
  

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Clinical trial in progress

 
EDUCATION TECHNOLOGY
Self-Directed & Distance Learning Systems

IEEE Transactions on Learning Technologies
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Our article about Hand Avatar is published in the



  A software development for 3D textured digitalisation and annotation of human cadaveric specimens for distance learning, revision, lab manual and 
multiviewer Hololens mixed reality implementation for holographic cadaveric teaching/learning.

INTERNATIONALISATION OF THE CURRICULUM GRANT PROJECT
 

HOLOGRAPHIC Interactive Visual System-  
Interactive ANATOMY and PATHOLOGIES

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IMPACT

IN THE NEWS

NZHerald, NZ 2017 May
Otago Daily Times , NZ 2017 May
NZdoctor.co.nz, NZ 2017 May
Voice of America , US 2016 May
Fox tv TR 2016
Newsweek TR 3 issues,cover in 2012
Science Focus TR 2011 March

SPONSORS

Medtech Core NZ
Otago Innovation NZ
Inventram TR/ Mitsui JPN

COLLABORATORS

SouthWest Research Institute US
Columbia University US
Harvard-Singapore University 
Maastricht University NL
Auckland University NZ
Auckland Bioengineering Institute NZ
Sydney University, AU
New York University, US
Koc University TR
Codeflugel, AUSTRIA
Soterix, NY,US
Parkinson Study Group, US

NeSI-HPC supercomputer, NZ
Johns Hopkins University, US
Fisher & Paykel Healthcare, NZ
 

PATENTS

A system for decreasing the blood flow of a targeted organ's artery with an electrical stimulation
WO2014183790 A1
Granted in US, EU & Japan
 
An electrostimulation device for PD
WO 2014207512 A1
Granted in EU and US

A system for Monitoring Auditory Startle Response 
US16/695,103 

Electrostimulation device for the external ear canal
PCT/TR2016/050176

Electrostimulation device effective in muscle localisation identification and therapeutic response enhancement
PCT/TR2016/050064

A system for decreasing the blood glucose level
PCT/TR2016/000016

A system for decreasing the blood pressure
PCT/TR2016/000017

A system for Monitoring Auditory Startle Response: Mobile monitoring of the Startle reflex
with intrinsic auricular muscles and camera-based systems
US15/642,287 209/000845 A1

Non-Invasive Stimulation Device for Synchronous stimulation of Sternocleidomastoid muscles and four
of the cutaneous Cervical nerve Branches with their autonomic connections
PCT/TR2019/051093

 

LAB      MEMBERS

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Prashanna Khwaounjoo, PhD

Postdoctoral Researcher
Data Scientist

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Burak Ozsoy, PhD

Postdoctoral Researcher
Parkinson Device Start-up Company Operations Manager

Ashim Maharjan, MSc

PhD Candidate 
 

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Susannah Lumsden, MSc

PhD Candidate

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Alexander Yang, BSc

PhD Canditate

Chris Gowen, BSc

MSc Candidate 
 

Johanna Mathieson 

BMedSci 

Nikyta Chesney

PGDipSci 

Susanne Feringa

Internship student 
(from University of Groningen)

Mendy Zaal

Internship student (MSc)
(from University of Leiden)

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Working Hard

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Avatar 102
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   ALUMNI 2018-2020
     
   

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Chris Wang

BMedSc(Hons)

Uliana Sekene

PGDipSci 

Gurleen Singh

PGDipSci 

Catherine Spicer

PGDipSci 

Ashim Maharjan

MSc
 

Chris Gowen

PGDipSci
 

Alexander Yang

PGdipSci

USguidedTMScourse4EuropeanMedicalStudent
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            Dr.Cakmak performed a live demonstration & lecture
on Neuronavigation guided Transcranial magnetic stimulation  
    for the European Medical Student Association - EMSA 

 
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Muscular Hand Avatar was in the Science Expo 2016

Southwest Research Institute (Texas)
produced the first prototype for our innovation- the blood flow modulation device
 (Granted in Japan and US ) 

 We have been invited to Voice of America Washington to talk about our innovation.

 INVENTRAM & MITSUI  

       We had positive results in clinical
trials and 
Inventram & Mitsui  proceeded
 with launching STOParkinson company and new product design for our non-invasive 
wearable device for Parkinson's Disease.
    We will be running another US-based multicentric clinical trial in 2020-21. 
  


 

HOT NEWS

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We started a novel biomedical device research in Charles Perkins Centre,
Hybrid Theatre at the University of Sydney
 with Siemens iflow technology.

Kudos to our great team and Siemens support.

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Alex and Gurleen presented 2 of our lab 
projects in Texpo

 

TEXPO 
 2019

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We performed our first meeting with FDA (The Food and Drug Administration, a federal agency of the United States Department of Health and Human Services) for our wearable stimulator for Parkinson's Disease in 2020.

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MEETING

   PhD OPPORTUNITIES ARE AVAILABLE FOR MSc GRADUATES WITH A+
               
with a Scholarship possibility for suitably qualified applicants